黄连素

研究发现黄连素有助降血糖

上海交通大学医学院附属瑞金医院、上海市内分泌代谢病临床医学中心宁光教授等研究发现,小檗碱,也就是黄连素的主要成分,能显著改善2型糖尿病病情,特别是对合并高血脂及胰岛素抵抗的患者,能明显降低其血糖、血脂等指标。

治疗腹泻的常用药黄连素能降血糖!近日,上海交通大学医学院附属瑞金医院、上海市内分泌代谢病临床医学中心宁光教授等研究发现,小檗碱,也就是黄连素的主要成分,能显著改善2型糖尿病病情,特别是对合并高血脂及胰岛素抵抗的患者,能明显降低其血糖、血脂等指标。此研究结果日前发表于《临床内分泌学与代谢杂志》上。

据介绍,该研究共纳入初发的2型糖尿病患者116例,这些患者均血脂升高,且未接受过任何降糖、降脂治疗。他们在严格饮食控制和合理运动的基础上,按双盲随机原则被分至小檗碱治疗组和安慰剂对照组。

3个月后研究者发现,与治疗前相比,治疗组的空腹血糖、口服糖耐量试验(OGTT)检测的餐后2小时血糖、糖化血红蛋白(HbA1c)水平等均有明显下降。

研究者认为,小檗碱的降糖效果已接近目前常用的降糖药。另外,通过胰岛素抵抗评估“金标准”——高胰岛素正葡萄糖钳夹技术检测显示,接受小檗碱治疗的患者,其体内的胰岛素抵抗得到了一定程度的改善。且治疗组血清甘油三酯、总胆固醇及低密度脂蛋白胆固醇(即坏胆固醇)水平也显著降低。

不过,小檗碱也存在一定副作用,主要为轻度胃肠道症状,其中以便秘为多,但多数患者症状能自行缓解。整个研究过程中无低血糖反应及严重不良事件发生。研究者表示,对上述结论的系统证实,还有赖长期大规模的前瞻性研究。

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