山楂

山楂 – 助消化降血脂养颜美容

山楂,又叫红果、朹子,蔷薇科落叶小乔木,树皮暗灰色,有浅黄色皮孔,小枝紫褐色,单叶互生或于短枝上簇生,叶片宽卵形,伞房花序,花白色,后期变粉红色,果实球形,熟后深红色,表面具淡色小斑点。花期5-6月,果期7-10月。果实酸甜可口,能生津止渴,亦可入药,入药归脾、胃、肝经,有消食化积、活血散瘀的功效。山楂树适应能力强,容易栽培,树冠整齐,枝叶繁茂,病虫危害少,花果鲜美可爱,因而也是田旁、宅园绿化的良好观赏树种。

山楂 – 用药禁忌

  1. 脾胃虚弱者慎服。
  2. 《纲目》:生食多,令人嘈烦易饥,损齿,齿龋人尤不宜。
  3. 《本草经疏》:脾胃虚,兼有积滞者,当与补药同施,亦不宜过用。
  4. 《得配本草》:气虚便搪,脾虚不食,二者禁用。服人参者忌之。
  5. 《随息居饮食谱》:多食耗气,损齿,易饥,空腹及羸弱人或虚病后忌之。

山楂 – 药理作用

  1. 对心血管系统的作用: 山值含有脂肪酶,能促进脂肪消化,并能增加胃消化酶的分泌,促进消化。对胃肠功能具有一定调节作用,对活动亢进的免十二指肠平滑肌呈抑制作用,面对松弛的大鼠胃平滑肌有轻度的增强收缩作用。山植酸提取液及水溶液对乙酰胆碱及Ba\2引起免、鼠离体胃肠平滑肌收缩具有明显抑制作用,而对大鼠弛张状态下的胃平滑肌具有促收缩作用。
  2. 对心血管系统的作用:对心脏的作用山植提取物使在体、离体蟾蜍心收缩力增强,且持续时间长。山植酸对疲劳衰弱的蟾蜍心脏停博有恢复跳动的作用。山楂内所含的三萜酸能改善冠脉循环而使冠状动脉性衰竭得以代偿,达到强心作用。山植制剂对豚鼠的心脏能引起显著持久的扩张冠脉作用,并增强心博能力。北山植提取物4g/kg给豚鼠静脉注射连续6d,对异丙肾上腺素造成的心肌损伤有一定保护作用。山楂可增加冠脉流量,降低心肌耗氧量,对心肌缺血、缺氧有保护作用。山植浸膏以及总黄酮甙给犬静脉注射,冠脉血流量可增加37.5%,心肌耗氧量开始稍有增加,但随后逐渐减少。山植黄酮对免实验性急性心肌梗死模型能缩小心肌梗死的范围,减轻S-T段改变。山植流浸膏对动物垂体后叶素、异丙肾上豚素所致急性心肌缺血有一定保护作用。给狗喂饲山植(含原矢菊甙元低聚物)以后,其左心室血流量增加可达数小时之久,最大增加量可达平时血流量的70%,给猫静脉注射原矢菊甙元低聚物,也可使其心脏血流量呈剂量依赖性地增加,并使动脉血压略有下降。山楂浸膏对垂体后叶索引起的心律不齐有一定的抑制作用,三萜烯酸类能增加冠状动脉血流量,提高心肌对强心甙作用的敏感性,增加心排出量,减弱心肌应激性和传导性,具有抗心室颤动、心房颤动和阵发性心律失常等作用。
  3. 降脂作用:山植提取物和醇浸膏0.5mg/kg口服能使动脉粥样硬化兔血中卵磷脂比例提高,胆固醇和脂质在器官上的沉积降低。南山楂粉口服有降低实验性高脂血症兔的血清总胆固醇和β脂蛋白的作用,血清β脂蛋白的降低值亦类似。15%、30%的山楂浸膏对乳幼大白鼠有降脂作用,其中以30%的山楂浸膏为显著。豚鼠服用山楂水煎剂后,对胆固醇含成酶活力有抑制作用,可使其肝细胞微粒体及小肠粘膜的羟甲基戊二酰铺酶A还原酶活力分别下降70%和67%左右。山里红水浸膏能显著降低血清总胆固醇含量,其作用显著大于泛硫乙胺,并能明显增加血清中HDL-C、HDL2-C、HDL3-C浓度,其作用可能是通过提高血清中HDL及其亚组分浓度,增加胆固醇的排泄而实现的。
  4. 抗氧化作用:山楂水提取液有清除O/2自由基、抑制小鼠肝脏脂质过氧化反应,减低经O/2诱导的透明质酸解聚作用。
  5. 对免疫功能的作用:山楂的水煎醇沉制成的注射液皮下注射给药连续9d,可使家兔血清溶菌酶活性、血清血凝抗体滴度、心血T淋巴细胞E玫瑰花环形成率及T淋巴细胞转化率均显著增强,提示有免疫增强作用。
  6. 抗菌作用:山楂对志贺痢疾杆菌、福氏痢疾杆菌、宋内痢疾杆菌等有较强的抗菌作用;对金黄色葡萄球菌、乙型链球菌。大肠杆菌、变形杆菌、炭疽杆菌、白喉杆菌、伤寒杆菌、绿脓杆菌等也有抗菌作用;一般对革兰阳性细菌作用强于革兰阴性细菌。
  7. 防癌作用:在胃液的PH条件下,山楂提取液能够消除合成亚硝胺的前体物质,即能阻断合成亚硝胺。山楂提取液对大鼠和小鼠体内合成甲基苄基亚硝胶诱癌有显著的阻断作用。而山楂的丙酮提取液经对致癌剂黄曲霉素B1诱导TA98移码型、TA100碱基置换突变株回复突变抑制作用实验表明:山楂对黄曲霉素BI的致突变作用有显著抑制效果。说明山楂可能对预防肝癌有意义。
  8. 其他作用:山楂2.5g/kg腹腔注射能显著延长小鼠戊巴比妥钠睡眠持续时间。山植有收缩子宫、促进子宫复原、止痛作用。
  9. 毒性:山楂的聚合黄烷类成分小鼠腹腔和皮下注射的LD5O外分别为130mg/kg、300mg/kg;10%的山楂浸膏给雄性大鼠及小鼠口服,不久出现镇静作用,30min后死于呼吸衰竭,小鼠的 LD50为18.5ml/kg,大鼠的LD50为33.8ml/kg;10%的山楂总皂甙亦不会引起兔的溶血作用[4]。

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